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目的:探究人乳头瘤病毒检测在CIN及宫颈癌术后随访中的现实价值。方法:择取2015年1月-2016年1月我院收治的60例CIN者为研究对象。另取70例同期接收的宫颈癌者为对照组,分析两组子宫病变者HPV即时检测结果以及术后半年、一年的阳性率与术前对比情况。结果:宫颈癌者的HPV阳性率为95.71%,CIN-Ⅰ阳性率为78.94%,CIN-Ⅱ组为80.00%,CIN-Ⅲ组为95.24%。随着疾病进展,HPV感染率上升,组间数据存在显著差异,P<0.05.在60例CIN病患中,术后1年阳性人数为23.33%,术后半年阳性人数为8.33%,上述两组数据显著比术前低,P<0.05.宫颈癌患者中,术后1年阳性人数为57.14%,术后半年阳性人数为32.86%,上述两组数据显著比术前低,P<0.05.结论:对于CIN者实施HPV检测,可提升鉴别宫颈上皮内瘤病变和其他疾病的鉴别率。其对于判断CIN预后情况,有着相当重要的临床价值,值得进一步推广使用。
Objective: To explore the practical value of detecting human papillomavirus (HPV) in CIN and cervical cancer postoperative follow-up. Methods: Sixty CIN patients admitted from January 2015 to January 2016 in our hospital were selected as the study subjects. Another 70 patients received cervical cancer over the same period as the control group, analysis of two groups of uterine lesions in patients with HPV test results and postoperative six months, one year positive rate compared with the preoperative situation. Results: The positive rate of HPV in cervical cancer was 95.71%, the positive rate of CIN-Ⅰ was 78.94%, the rate of HPV was 80.00% in CIN-Ⅱ group and 95.24% in CIN-Ⅲ group. As the disease progressed, the HPV infection rate increased, there was a significant difference between the two groups of data, P <0.05.Among 60 CIN patients, the positive number was 23.33% at 1 year after operation and 8.33% at 6 months after operation, The data of the two groups were significantly lower than those before operation (P <0.05). Among the patients with cervical cancer, the positive rate was 57.14% at 1 year after operation and 32.86% at 6 months after operation. Conclusion: The implementation of HPV testing for CIN patients can improve the identification of cervical intraepithelial neoplasia and other diseases. It has a very important clinical value for judging the prognosis of CIN and is worth further promotion and use.