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目的探讨甘精胰岛素与阿卡波糖联合治疗老年2型糖尿病患者的可行性及优势。方法老年2型糖尿病患者胰岛素强化治疗血糖稳定后,将64例老年2型糖尿病患者随机分为应用甘精胰岛素组(A组)和预混胰岛素组(B组),A组采用甘精胰岛素与阿卡波糖联合治疗,B组采用预混胰岛素2次/d皮下注射,比较治疗后两组低血糖发生率、胰岛素使用剂量、平均空腹血糖、平均餐后血糖、糖化血红蛋白、体质量指数等。结果两组治疗后平均空腹血糖、平均餐后血糖、糖化血红蛋白、体质量指数方面比较差异无统计学意义(P>0.05)。但A组在胰岛素用量、低血糖发生率等方面均低于B组(P<0.05)。结论甘精胰岛素与阿卡波糖联合治疗方案对于老年2型糖尿病患者安全、有效、方便,低血糖发生率小。
Objective To investigate the feasibility and advantages of combining insulin glargine and acarbose in the treatment of elderly type 2 diabetic patients. Methods Aged patients with type 2 diabetes mellitus were treated with insulin glargine and insulin glargine at a stable glucose level. Sixty-four elderly patients with type 2 diabetes mellitus were randomized into insulin glargine group (group A) and premixed insulin group (group B) Acarbose combination therapy, B group using premixed insulin 2 times / d subcutaneous injection, compared the incidence of hypoglycemia, insulin dosage, mean fasting blood glucose, mean postprandial blood glucose, glycosylated hemoglobin, body mass index, etc. . Results After treatment, the average fasting blood glucose, mean postprandial blood glucose, glycosylated hemoglobin and body mass index showed no significant difference (P> 0.05). However, the amount of insulin and hypoglycemia in group A were lower than that in group B (P <0.05). Conclusion The combination therapy of insulin glargine and acarbose is safe, effective and convenient for patients with type 2 diabetes mellitus and the incidence of hypoglycemia is small.