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目的探讨脂联素基因两个单核甘酸位点多态性与汉族人群肥胖易感性的关系。方法选取肥胖组483例,对照组517例为研究对象,用RT-PCR联合TaqMan-MGB探针检测基因型。结果携带脂联素基因rs2241767AG和AG/GG基因型者较AA基因型者发生肥胖的风险增加,尤其在男性、<50岁、高血脂或不吸烟/戒烟群体中,AG/GG基因型者发生肥胖的风险增加。女性携带该基因rs12495941位点GT/TT型较GG型者发生肥胖的风险增加。结论脂联素基因两位点(rs2241767、rs12495941)多态性改变可能与汉族人群肥胖有关。
Objective To investigate the association of adiponectin gene polymorphisms at two SNPs with susceptibility to obesity in Han population. Methods 483 cases of obesity group and 517 cases of control group were selected as the research object. Genotypes were detected by RT-PCR combined with TaqMan-MGB probe. Results There was an increased risk of obesity in AA genotypes with rs2241767AG and AG / GG genotypes, especially those with AG / GG genotypes in men, <50 years of age, hyperlipidemia or non-smoking / smoking cessation groups Increased risk of obesity. Women carrying this gene rs12495941 site GT / TT type than GG type increased risk of obesity. Conclusion The polymorphism of adiponectin gene two loci (rs2241767, rs12495941) may be related to obesity in Han population.