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我所在临床及以往保元汤药效研究(1～3)的基础上,进一步研究和观察了保元汤对内.毒素性休克动物的影响,报告如下:材料与方法体重100～150g Wistar 种大白鼠68只,采用组间比较的设计方案,随机分组。每组10或14只,雌雄各半。以0.1mg/kg 体重(≈LD_(50)),静脉注射大肠杆菌内毒素(卫生部生物制品研究所生产,批号81—1),诱发以急性全身性 DIC 为基础的中毒性休克。保元汤冲剂(中医研究院中药研究所生产,批号80—3,人参、黄芪、桂枝、甘草的组成比例为5:
Based on my clinical and previous efficacy studies (1 to 3) of Baoyuan Decoction, we further studied and observed the effect of Baoyuan Decoction on endotoxin-induced shock animals, and reported the following: Materials and Methods Weight 100-150 g Wistar species Sixty-eight mice were randomly divided into groups using a design scheme for comparison between groups. Each group has 10 or 14 males and females. At a dose of 0.1 mg/kg body weight (≈LD_(50)), E. coli endotoxin (produced by the Ministry of Health, Institute of Biological Products, Batch No. 81-1) was intravenously administered to induce acute systemic DIC-based toxic shock. Bao Yuan Tang granules (made by the Institute of Traditional Chinese Medicine of the Chinese Academy of Medical Sciences, batch number 80-3, the ratio of ginseng, astragalus, cassia twig, and licorice is 5: