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大鼠感染~(125)I标记的约氏疟原虫子孢子后2h,子孢子在肝、脾、肺的含量分别为1.67％、0.046％、0.49％。2～18 h子孢子在肝的分布下降缓慢;脾内基本保持恒定;肺内下降较快。活体灌注子孢子,较大流速不影响肝对子孢子的拘捕率,但使肺的拘捕率显著降低。巨噬细胞吞噬活性增加的大鼠肝、脾脏内子孢子含量高于巨噬细胞吞噬活性受抑制的大鼠,肺内子孢子含量不受巨噬细胞吞噬活性影响。实验结果表明肺对子孢子的拘捕主要为机械性拘捕,肺巨噬细胞在子孢子入侵过程中的作用不大;肝、脾对子孢子的拘捕以巨噬细胞的生物性拘捕为主。
After 2 h of infection with 125I-labeled P. yoelii sporozoites, the sporozoites in the liver, spleen, and lung were found to be 1.67%, 0.046%, and 0.49%, respectively. The distribution of sporozoites in the liver decreased slowly from 2 to 18 h; the spleen remained basically constant; the lungs declined rapidly. In vivo perfusion of sporozoites, the larger flow rate does not affect the rate of arrest of the liver to sporozoites, but the lung arrest rate is significantly reduced. Rats with increased macrophage phagocytic activity had higher levels of sporozoites in the liver and spleen than rats with suppressed macrophage phagocytic activity. The sporozoite content in the lung was not affected by the phagocytic activity of macrophages. The experimental results showed that the arrest of the sporozoites in the lungs was mainly mechanical arrest. The role of pulmonary macrophages in the invasion of sporozoites was not significant. The arrest of sporozoites by the liver and spleen was mainly due to the biological arrest of macrophages.