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胸腺上皮性肿瘤形态多样,成分复杂,常常伴有副瘤综合症,以重症肌无力为主。其分类变化较大,争议多。该文概述了胸腺上皮肿瘤分类的发展,重点回顾了2004年WHO胸腺上皮肿瘤的分类。并从分子生物学标记和遗传学方面对胸腺上皮肿瘤分类与其预后的关系进行了介绍。随着研究的全面和深入,对胸腺上皮性肿瘤生物学行为的认识也更为透彻,分类更完善,势必改进临床的诊断治疗水平。
Thymic epithelial tumors in various forms, composition is complicated, often accompanied by paraneoplastic syndrome, with myasthenia gravis based. The classification changes a lot, many controversies. This article summarizes the development of thymic epithelial tumor classification, focusing on reviewing the 2004 WHO classification of thymic epithelial tumors. The relationship between the classification of thymic epithelial tumor and its prognosis was introduced from molecular biology markers and genetics. With the comprehensive and in-depth study, the understanding of the biological behavior of thymic epithelial tumors is more thorough and the classification is more perfect, which is bound to improve the clinical diagnosis and treatment.