合成了一系列具有生理活性化合物-苯并噻唑腙。2-氨基苯并噻唑及6-取代-2-氨基苯并噻唑经重氮化后与含活泼亚甲基化合物偶联,如,2,4-戊二酮,丙二腈,氰乙酸乙酯和丙二酸亚异丙酯,形成相应的苯并噻唑腙,并初步研究了这类腙的灭菌活性。实验结果表明,苯并噻唑腙对金黄色葡萄球菌生长具有明显的抑制作用。 A series of physiologically active compounds, benzothiazolylhydrazone, were synthesized. 2-Aminobenzothiazole and 6-substituted-2-aminobenzothiazoles are diazotized and coupled to an active methylene-containing compound such as 2,4-pentanedione, malononitrile, ethyl cyanoacetate And isopropylidene malonate to form the corresponding benzothiazolyl hydrazone, and preliminary study of the sterilizing activity of such hydrazones. The experimental results show that benzothiazolyl hydrazone has a significant inhibitory effect on the growth of Staphylococcus aureus.