【Objective】 The study was aimed to assess the state of antigen-presenting cells(APC) and humoral immunity in the female genital tract during the HPV-infection.【Method】 This study was conducted at the sample of 30 females with verified HPV-infection.30 healthy females were examined as a control.The functional state of APC was determined immunohystochemically by the frequency of the positive reaction to the major histocompatibility complex(MHC)-CII,CD1a and langerine in the samples of cervical tissue.The following monoclonal antibodies were used: anti-DR(Dako),anti-CD1a(Dako) and anti-Langerine(LIR,Dardilly).The obtained data were analyzed statistically with performing Mann-Whitney test for independent samples.The data were analyzed using the software Statistica 7.0(StatSoft Inc.,USA) for Windows.【Result】 There was determined that the patients with the genital HPV-infection had the moderate deficiency of sIgA,IgА and IgG whereas IgM activity wasn’t changed.They were also experienced the decrease of CD1a+ cells population as well as NHC-CII and Langerine+ DC in the cervical epithelium.【Conclusion】There is discussed the expedience to include the assessment of the functional state of APC of the patients with the HPV-infection into the national clinical protocols.