This study reports zircon U-Pb and Hf isotopes and whole-rock elemental data for granodiorites from the East Kunlun orogen. The zircon U-Pb dating defines their crystallization age of 235 Ma. The rocks are characterized by high-K calc-alkaline, magnesian and metaluminous with(K_2O+Na_2O)=6.38 wt.%–7.01 wt.%, Mg#=42–50 [Mg#=100×molar Mg/(Mg+Fe OT)], A/CNK=0.92–0.98, coupled with high εHf(t) values from-0.65 to-1.80. The rocks were derived from partial melting of a juvenile mafic crustal source within normal crust thickness. The juvenile lower crust was generated by mixing lithospheric mantle-derived melt(55%–60%) and supracrustal melt(40%–45%) during the seafloor subduction. Together with available data from the East Kunlun, it is proposed that the studied Middle Triassic granodiorites were formed in post-collisional extension setting, in which melting of the juvenile lower crust in response to the basaltic magma underplating resulted in the production of high-K granodioritic melts. This study reports zircon U-Pb and Hf isotopes and whole-rock elemental data for granodiorites from the East Kunlun orogen. The zircon U-Pb dating defines their crystallization age of 235 Ma. The rocks are characterized by high-K calci- alkaline, magnesian and metaluminous with (K 2 O + Na 2 O) = 6.38 wt.% - 7.01 wt.%, Mg # = 42-50 [Mg # = 100 × molar Mg / (Mg + Fe OT)], A / CNK = 0.92-0.98 , coupled with high εHf (t) values ​​from-0.65 to-1.80. The rocks were derived from partial melting of a juvenile mafic crustal source within normal crust thickness. The juvenile lower crust was generated by mixing lithospheric mantle-derived melt (55% -60%) and supracrustal melt (40% -45%) during the seafloor subduction. Together with available data from the East Kunlun, it is proposed that the studied Middle Triassic granodiorites were formed in a post-collisional extension setting, in which melting of the juvenile lower crust in response to the basaltic magma underplating resulted in the production of high-K granodioriti c melts.