肝硬化门脉高压并发食管静脉曲张破裂出血 (ＥＶＢ) ,其首次病死率高达 3 0 %～ 5 0 % ,而且以后常有复发性再出血 ,进一步危及患者生命。我们近年来将心得安与螺内酯联用于预防ＥＶＢ再出血 ,取得较为满意疗效 ,现报告如下。1　资料与方法1.1病例选择　 74例患者依据临床表现 Cirrhosis of the portal hypertension with esophageal variceal bleeding (EVB), the first case fatality rate as high as 30% ~ 50%, and often have recurrent hemorrhage later, further endangering the patient’s life. In recent years, we will propranolol and spironolactone combination in the prevention of EVB rebleeding, achieved more satisfactory results, are as follows. 1 Materials and Methods 1.1 Case Selection 74 patients based on clinical manifestations