目的:探讨妊娠早期正常妊娠组与先兆流产组孕妇血清人绒毛膜促性腺激素(HCG)、孕酮(P)和雌二醇(E2)水平的浓度差异,探讨其在维持早孕中的作用。方法:收集我院2012年12月~2013年12月妇科门诊就诊且经临床检查及B超证实为宫内早孕并定期孕检的800例妇女分为正常妊娠组和先兆流产组各400例,采用化学发光分析法检测孕妇血清中HCG、P和E2水平。结果:两组孕妇HCG、E2水平与孕周均呈正相关,P水平与孕周无相关性。同一孕周正常妊娠组β-hCG、P和E2浓度比先兆流产组高。两组同一孕周比较HCG:4-6+6孕周水平无明显差异,但>7孕周两组存在明显差异;P:4-8+6孕周水平差异有统计学意义,9~12+6孕周水平差异无统计学意义;E2:两组各孕周水平差异均有统计学意义。结论:血清β-hCG、P和E2水平是维持早孕的重要指标,联合定期监测可及早发现先兆流产并预测其预后。 Objective: To investigate the difference of serum concentration of human chorionic gonadotropin (HCG), progesterone (P) and estradiol (E2) between normal pregnancy group and threatened abortion group in early pregnancy and to explore its role in maintaining early pregnancy. Methods: A total of 800 women from our hospital from December 2012 to December 2013 who were treated by gynecological clinic and clinically confirmed by B-ultrasound and who were confirmed by intrauterine early pregnancy and regular pregnancy test were divided into 400 cases of normal pregnancy group and threatened abortion group. The levels of HCG, P and E2 in serum of pregnant women were detected by chemiluminescence analysis. Results: The levels of HCG and E2 in both groups were positively correlated with gestational age, and there was no correlation between P level and gestational age. Β-hCG, P and E2 concentrations in normal pregnancy group were higher than those in threatened abortion group in the same gestational week. There was no significant difference between the two groups in the same gestational age HCG: 4-6 + 6 gestational weeks, but there was a significant difference between the two groups in> 7 gestational weeks; P: 4-8 + 6 gestational weeks the difference was statistically significant, 9-12 +6 gestational weeks no significant difference between the level; E2: the two groups of gestational weeks were statistically significant differences. Conclusion: Serum β-hCG, P and E2 levels are important indicators of early pregnancy, combined with regular monitoring of threatened abortion can be found early and predict its prognosis.