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Objective: To test the hypothesis that statins improve hyperandrogenemia in women with polycystic ovary syndrome (PCOS).Design: Prospective, randomized trial.Setting: Academic medical center.Patient(s): Forty- eight women with PCOS.Intervention(s): Subjects were randomized to a statin group (simvastatin, 20 mg daily plus oral contraceptive pill [OCP]; n = 24) or an OCP group (OCP alone; n = 24).Main Outcome Measure(s): Serum T.Result(s): Baseline parameters of both groups were comparable.After 12 weeks of treatment, serum T levels declined by 41% in the statin group and by 14% in the OCP group.In the statin group, there was a greater decrease of LH (43% decrease vs.9% in the OCP group) and a greater decline of LH/FSH ratio (44% vs.12% ).In the statin group, total cholesterol declined by 10% and low- density lipoprotein (LDL) by 24% .In the OCP group, total cholesterol increased by 8% , and LDL was unchanged.Conclusion(s): This is the first study demonstrating that statin decreases T levels and normalizes gonadotropin levels in women with PCOS.Statin therapy might offer a novel approach, providing endocrine and cardiovascular benefits.
Objective: To test the hypothesis that statins improve hyperandrogenemia in women with polycystic ovary syndrome (PCOS). Design: Prospective, randomized trial. Letting: Academic medical center. Patient (s): Forty- eight women with PCOS. Intervention Subjects were randomized to a statin group (simvastatin, 20 mg daily plus oral contraceptive pill [OCP]; n = 24) or an OCP group (OCP alone; n = 24) Serum T levels declined by 41% in the statin group and by 14% in the OCP group. the statin group, there was a greater decrease of LH (s): Baseline parameters of both groups were comparable. 43% decrease vs.9% in the OCP group) and a greater decline of LH / FSH ratio (44% vs. 12%) .In the statin group, total cholesterol declined by 10% and low-density lipoprotein 24%. In the OCP group, total cholesterol increased by 8%, and LDL was unchanged. Conlusion (s): This is the first study demonstrating that statin decreases T le vels and normalizes gonadotropin levels in women with PCOS. Statin therapy might offer a novel approach, providing endocrine and cardiovascular benefits.