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为了观察吖啶诱变无产卵能力的血吸虫是否能诱生抗感染的保护性免疫力，用 １０ μｇ／ｍ ｌ吖啶诱变剂 Ｉ Ｃ Ｒ１７０ 致弱日本血吸虫尾蚴作免疫原，免疫 Ｃ５７ Ｂ Ｌ／６ Ｎ 小鼠两次，分别于初次免疫后６、８、１０ ｗ ｋ 用正常尾蚴作攻击感染。结果免疫鼠成虫减少率为６８．９％ ，肝组织虫卵减少率为７４．９％ 。动态观察显示，初次免疫后６ ｗ ｋ 攻击感染的减虫率最高，减卵率高峰在６～８ ｗ ｋ。表明诱变剂 Ｉ Ｃ Ｒ１７０ 致弱日本血吸虫尾蚴发育的变异成虫具有较高的免疫原性，可诱导较高的抗攻击感染的保护性免疫力。
In order to observe the ability of acridine-induced oviposition of schistosomiasis can induce protective immunity against infection, with 10 μg / ml acridine mutagen I C R 170 weak Schistosoma japonicum cercariae as an immunogen, immunization C57 B L / 6 N mice were challenged with normal cercariae at 6, 8 and 10 wk after primary immunization, respectively. Results The reduction rate of immunized mice was 68.9%, and the reduction rate of liver tissues was 74.9%. Dynamic observations showed that the highest worm reduction rate was observed at 6 weeks after primary immunization, with the highest egg reduction rate of 6-8 w k. It showed that mutants I C R 170 attenuated Schistosoma japonicum cercariae development of adult worm has high immunogenicity, can induce a higher protective immunity against attack.