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目的 HIV感染者由于免疫力低下导致各种机会性感染,中草药和化学药物联合用药的现象十分普遍。但是中草药成分复杂,可能影响抗病毒化学药物的有效性、安全性,引起HIV耐药等问题。本研究综述中草药与抗艾滋病病毒化学药物相互作用的研究进展。方法从百度(www.baidu.com)和Pubmed(http://www.ncbi.nlm.nih.gov/pubmed/)中搜索有关“中草药(herb)、抗艾滋病病毒药物(anti-HIV drugs)、药物与药物相互作用(drug-drug interaction)”的文献,然后进行归纳整理。结果综述了中草药与化学药物联合用药现状,中草药对抗病毒化学药物的药动学影响以及对CYP450代谢酶的作用。结论系统地综述了中草药与抗艾滋病病毒化学药物的相互作用,为临床合理用药提供参考。
Objective HIV infection due to low immunity lead to a variety of opportunistic infections, the combination of Chinese herbal medicine and chemical drugs is widespread. However, the complex composition of Chinese herbal medicine may affect the effectiveness of anti-viral chemicals, safety, HIV resistance and other issues. This review summarizes the research progress of the interaction between Chinese herbal medicine and anti-HIV drugs. METHODS: Baidu (www.baidu.com) and Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/) searched for “herb, anti-HIV drugs, Drug-drug interaction ”, and then summarize them. Results The current situation of the combination of Chinese herbal medicine with chemical drugs, the influence of Chinese herbal medicine on the pharmacokinetics of anti-virus chemical drugs and the effect on CYP450 metabolic enzymes were summarized. Conclusion The systematic review of the interaction between Chinese herbal medicine and anti-HIV drugs provides a reference for rational clinical use.