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目的:制备葛根素脂质体并研究大鼠对其的口服吸收。方法:利用薄膜分散-超声法制备脂质体,利用超滤法分离游离药物测定包封率,观测脂质体的微观形态与粒径分布;HPLC法测定葛根素脂质体大鼠口服后血浆中的药物含量。结果:脂质体对葛根素的包封率为53.0%,脂质体粒子在电镜下为圆形或椭圆形,粒径范围50-300nm;葛根素脂质体对其水溶液的相对生物利用度为168%。结论:脂质体对葛根素口服吸收有显著促进作用。
Objective: To prepare puerarin liposome and study its oral absorption in rats. Methods: The liposome was prepared by the membrane dispersion-ultrasonic method. The free drug was separated by ultrafiltration to determine the encapsulation efficiency, and the micro-morphology and particle size distribution of the liposome were observed. The puerarin liposomes were determined by HPLC after oral administration in rats. The drug content in the. RESULTS: The entrapment efficiency of liposome on puerarin was 53.0%, the size of liposome particles was circular or elliptical under electron microscope, and the particle size range was 50-300 nm; the relative bioavailability of puerarin liposomes to its aqueous solution. It is 168%. CONCLUSION: Liposomes have a significant effect on the oral absorption of puerarin.