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目的探讨上皮细胞钙黏蛋白(E-cadherin)和转移抑制基因(nm23-H1)表达与胰腺癌侵袭转移的关系。方法应用免疫组织化学技术SP法,检测31例癌组织中E-cadherin和nm23-H1的表达水平。结合肿瘤的侵袭转移能力、分化程度和分期等进行分析。结果31例胰腺癌组织中E-cadherin和nm23-H1的表达强度均低于对照的胰腺组织;E-cadherin和nm23-H1的表达强度与胰腺癌的远处转移能力密切相关;胰腺癌中E-cadherin和nm23-H1的表达具有明显正相关。结论E-cadherin和nm23-H1的表达水平能反映胰腺癌的侵袭转移能力。两种蛋白的表达水平之间呈明显正相关。联合检测两种蛋白在胰腺癌组织中的表达,对临床判断胰腺癌的预后可能有一定的意义。
Objective To investigate the relationship between the expression of E-cadherin and nm23-H1 and the invasion and metastasis of pancreatic cancer. Methods Immunohistochemical SP method was used to detect the expression of E-cadherin and nm23-H1 in 31 cases of cancer tissues. Combined with tumor invasion and metastasis, the degree of differentiation and staging analysis. Results The expression of E-cadherin and nm23-H1 in pancreatic cancer tissues was lower than that in the control. The expression of E-cadherin and nm23-H1 was closely related to the distant metastasis of pancreatic cancer. The expression of E There was a significant positive correlation between -cadherin and nm23-H1 expression. Conclusion The expression of E-cadherin and nm23-H1 can reflect the invasion and metastasis of pancreatic cancer. There was a significant positive correlation between the expression levels of the two proteins. Joint detection of two proteins in pancreatic cancer expression, the clinical diagnosis of pancreatic cancer may have some significance.