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垂体腺瘤是颅内常见的良性肿瘤 ,根据生长特点可分为非侵袭性和侵袭性垂体腺瘤 ,单纯从影像学及病理形态学特征研究很难客观评价垂体腺瘤的生物学行为及预后[1,2 ] 。本研究选择细胞增殖指标增殖细胞核抗原 (ＰＣＮＡ)和肿瘤抑制基因ｐ16作为观察指标 ,应用免疫组化检测其基因
Pituitary adenoma is a common intracranial benign tumor. According to the growth characteristics, it can be divided into non-invasive and invasive pituitary adenoma. It is difficult to objectively evaluate the biological behavior and prognosis of pituitary adenoma based on the imaging and histopathological features [1,2]. In this study, we selected the cell proliferation index of proliferating cell nuclear antigen (PCNA) and tumor suppressor gene p16 as the observation index, and detected its gene by immunohistochemistry