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50年代以前认为,休克的主要原因是外周动脉紧张度不足所致的血压下降;60年代提出了休克的微循环学说;70年代末休克的发病机理开始深入到细胞、亚细胞水平;80年代以来,自由基和休克之间的关系已经受到国内外学者的普遍重视。
Before the 1950s, the main reason for shock was the decrease in blood pressure caused by inadequate peripheral arterial pressure. The microcirculation theory of shock was proposed in the 1960s. The pathogenesis of shock in the late 1970s began to deepen into the cellular and subcellular levels. Since the 1980s , The relationship between free radicals and shock has been widespread attention of scholars at home and abroad.