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从麻风菌素和结核菌素阳性的正常人的外周血分离而得的活淋巴细胞输注给4例瘤型和1例结核样型麻风患者,每月一次,每次400万个活淋巴细胞共3次。其中3例瘤型患者患有麻风结节性红斑(ENL),另2例即使用1毫克氨苯砜亦出现严重的反应,故输注前均无抗麻风药物治疗。每次输注后,每例患者均出现反应或反应的强度增强,持续7～10天,除1例患者因ENL近5年每日服强的松龙20毫克此时需加量外,均不需治疗。输注后1例瘤型患者的临床状况未见改善,ENL发作的严重性及次数均未降低,余4例患者出现了临床、细菌学及组织学上的改善,ENL的严重性继每次输注而逐渐减轻,于研究期内(第一次输注后5个月内)ENL消失。之
Live lymphocytes isolated from the peripheral blood of leprosycin and tuberculin-positive normal individuals were infused into 4 patients with tuberculosis and 1 patient with leprosy, once a month for 4 million live lymphocytes A total of 3 times. Three of these patients had leprosy erythema (ENL), and the other 2 patients experienced severe reactions even with 1 mg dapsone. Therefore, no anti-leprosy drugs were administered prior to infusion. Each infusion, each patient showed increased response or reaction intensity, lasting 7 to 10 days, except for 1 patient due to ENL nearly 5 years of daily doses of prednisolone 20 mg at this time need to add, are Without treatment. The clinical status of one patient with tumor did not improve after infusion. The severity and number of ENL attacks did not decrease. Clinical, bacteriological and histological improvement were observed in the remaining four patients. Infusion gradually reduced, ENL disappeared during the study period (within 5 months after the first infusion). It