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目的 :孕酮 (PROG)已被证明是一种”神经活性甾体” ,本文探讨PROG对缺血脑的神经保护作用。方法 :采用大鼠局灶性脑缺血再灌注模型 ,测定大脑中动脉阻塞 (MCAO) 2h再灌注 2 2h后纹状体水、钠、钾、钙含量。结果 :①I/R和DMSO组MCAO侧纹状体的水、钠、钙明显高于、钾显著低于非MCAO侧 ,I/R和DMSO组之间相比无显著差异 ;②与I/R和DMSO组相比 ,PROG预防及防治组MCAO侧纹状体的水、钠、钙明显减少 ,钾明显增加 (P <0 0 1) ;PROG治疗组则水、钠明显减少 ,但钾和钙无显著差异 (P >0 0 5 ) ;③PROG各组与阳性对照DEXA组相比 ,MCAO侧纹状体水、钠、钙、钾的差别均无显著 (P >0 0 5 )。结论 :PROG可减轻脑缺血 /再灌注大鼠纹状体的损伤。
PURPOSE: Progesterone (PROG) has been shown to be a “neuro-active steroid” and this article explores the neuroprotective effects of PROG on ischemic brain. Methods: The content of water, sodium, potassium and calcium in the striatum of rats after focal cerebral ischemia-reperfusion 2 h after middle cerebral artery occlusion (MCAO) was measured 2 h after reperfusion. Results: ① The water, sodium and calcium of MCAO in I / R and DMSO groups were significantly higher than those in the non-MCAO group, and there was no significant difference between I / R and DMSO groups. ② Compared with I / R Compared with the DMSO group, water, sodium and calcium in the striatum of the MCAO group in the PROG prevention and control group were significantly decreased and potassium was significantly increased (P <0.01); while in the PROG treatment group, water and sodium were significantly decreased, while potassium and calcium (P> 0.05). ③Compared with the positive control DEXA group, there was no significant difference in water, sodium, calcium, potassium in the lateral striatum between the groups of PROG (P> 0.05). Conclusion: PROG can reduce the damage of striatum in cerebral ischemia / reperfusion rats.