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本文研究小诺霉素渗透到特定组织如肺、前列腺和肾脏皮质及髓质中浓度与其相应血药浓度比值。对75名经过外科手术的病人进行研究。第1组为30名经外科手术的肺癌病人,第2组为25名患前列腺增生而进行前列腺手术的病人,第3组为20名经肾手术病人。手术前在不同时间间隔对每个病人肌注60mg小诺霉素,以便得到8小时期间各组织中药时曲线。第1组病人选作肺浓度测定,平均体重80.1±7.2kg,平均身高173.7±8.5cm,小诺霉素平均用量为0.76±0.07mg/kg。第2组病人选为肾浓度测定,平均体重84.8±6.6kg,平均身高176.4±9.1cm,小诺霉素平均用量为0.71±0.06mg/kg。第3组病人选作前列腺浓度测定,平均
In this paper, the concentration of minocycline infiltration into specific tissues such as lung, prostate and renal cortex and medulla in the corresponding concentrations of plasma concentration ratio. A study of 75 surgically treated patients. The first group consisted of 30 surgically-operated lung cancer patients, the second group consisted of 25 patients undergoing prostate surgery for BPH, and the third group consisting of 20 patients undergoing renal surgery. Each patient was intramuscularly injected with 60 mg of microtomycin at various time intervals prior to surgery to obtain a Chinese herbal time curve for each tissue over a period of 8 hours. The first group of patients selected for lung concentration determination, the average body weight of 80.1 ± 7.2kg, the average height of 173.7 ± 8.5cm, the average amount of minornomycin 0.76 ± 0.07mg / kg. The second group of patients selected for the determination of renal concentration, the average body weight of 84.8 ± 6.6kg, the average height of 176.4 ± 9.1cm, the average amount of minornomycin 0.71 ± 0.06mg / kg. Group 3 patients selected for prostate concentration, average