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本文报告286例各种肾脏病肾间质中淋巴细胞亚群的分析结果.正常肾间质散在分布少量CD_4~+细胞、CD_~+细胞及B~+细胞.局灶节段硬化肾炎、膜增肾炎、IgA肾病、狼疮肾炎、结节性多动脉炎及多种间质小管疾病间质中CD_4~+细胞、CD_~+细胞及B~+细胞数量著增多,CD_4~+/CD_~+细胞比值在狼疮肾炎一般<1,IgA肾病大都>1;系膜增殖肾炎、糖尿病肾病及内皮系膜增殖肾炎的CD_4~+细胞、CD_~+细胞及B~+细胞轻度增加;遗传肾炎、原发肾炎的轻微病变、IgM肾病、膜性肾病及高血压肾损害者等其CD_4~+细胞、CD_~+细胞及B~+细胞数量接近正常.间质中的T细胞数量与小管萎缩、间质纤维化程度以及血清肌酐值呈正相关.结果表明,分析肾间质淋巴细胞亚群可能有助于肾脏病的诊断,有助于判断病情的严重程度.细胞免疫可能参与间质小管损伤.
In this paper, we report the results of the analysis of lymphocyte subgroups in 286 cases of renal interstitial nephropathy.The normal renal interstitial scattered a small amount of CD 4 + cells, CD 5 + cells and B 5+ cells, focal segmental nephritis, The number of CD_4 ~ + cells, CD_ ~ + cells and B ~ + cells increased in the interstitial of interstitial tubulointerstitial nephropathy, nephritis, IgA nephropathy, lupus nephritis, polyarteritis nodosa and interstitial tubulointerstitial diseases. CD_4 ~ + / CD_ ~ Cell ratio in lupus nephritis is generally <1, IgA nephropathy mostly> 1; CD_4 ~ + cells, CD_ ~ + cells and B ~ + cells of mesangial proliferative glomerulonephritis, diabetic nephropathy and endothelial mesangial proliferative glomerulonephritis increased slightly; The number of CD_4 ~ + cells, CD_ ~ + cells and B ~ + cells in patients with mild primary nephritis, IgM nephropathy, membranous nephropathy and hypertensive renal impairment were close to normal.The number of T cells in stroma and atrophy of tubules, Interstitial fibrosis and serum creatinine.The results show that analysis of renal interstitial lymphocyte subsets may contribute to the diagnosis of kidney disease, help to determine the severity of the disease.Cell immunity may be involved in interstitial tubule injury.