用免疫荧光法检测了４５例非ＧＰＳ肾小球疾病患儿血清中ＩｇＧ型抗ＧＢＭ抗体，阳性１３例占２８％。两组在尿蛋白和血清ＢＵＮ定量等无明显差异。但对３０例（１０例阳性，２０例阴性）患儿随访３年表明，阳性组复发率和死亡率均高于阴性组（ｔ＝３．３８，χ２＝３．９，Ｐ均小于０．０５）。阳性组抗ＧＢＭ抗体滴度与肾受损程度和复发率呈正相关（ｒ分别为０．５６，０．８６）。提示部分非ＧＰＳ肾小球疾病与自身免疫有关。 Serum IgG anti-GBM antibodies were detected in 45 children with non-GPS glomerular diseases by immunofluorescence, and 13 were positive (28%). There was no significant difference between the two groups in urinary protein and serum BUN quantification. However, the follow-up of 3 years in 30 patients (10 positive and 20 negative) showed that the positive rate of recurrence and mortality were higher than that of the negative (t = 3.38, χ2 = 3.9, P <0). 05). Positive antibody titer of GBM was positively correlated with the extent of renal damage and recurrence (r = 0.56,0.86, respectively). Suggesting that some non-GPS glomerular diseases are related to autoimmunity.