本文报导在实验室为体外培养的恶性疟原虫配子体感染后子孢子阳性的蚊虫叮咬偶然传播恶性疟1例。一例52岁黑人,从事蚊虫和疟原虫的研究工作。从无疟史与受输血史,4年内未离开过美国。因每天一次的周期性发热与出汗7天伴有头痛头昏等于1982年6月30日入院。入院时,体温39.2℃,脉搏120次/分,血压120/60mm。体检:患者脸潮红、巩膜轻度黄疸,心肺正常,脾触及于左肋下2cm处,其它无异常发现。实验室检查,血细胞容量40%,白细胞4300/mm(?),嗜中性细胞75%,淋巴细胞21%、单核细胞2%、嗜酸粒细胞2%,血小板轻度减少,血清钠129mEq/L,其他电解物正常,尿检糖1+,胸透无异常,血涂 This article reports a case of sporadic transmission of falciparum malaria by sporozoites in mosquitoes infected with P. falciparum gametocytes in laboratory. A 52-year-old black man engaged in research on mosquitoes and malaria parasites. No history of malaria and history of blood transfusion, did not leave the United States within 4 years. Because once a day of periodic fever and sweating 7 days accompanied by headache dizziness equal to June 30, 1982 admission. At admission, body temperature 39.2 ℃, pulse 120 beats / min, blood pressure 120 / 60mm. Physical examination: Patients with flushing, mild scleral jaundice, normal heart and lung, spleen touched the left rib 2cm Department, no other abnormal findings. Laboratory tests showed that the hematocrit was 40%, leukocyte 4300 / mm (?), Neutrophil 75%, lymphocyte 21%, monocyte 2%, eosinophil 2%, platelet mildly reduced, serum sodium 129mEq / L, other electrolytes normal, urine glucose 1 +, no abnormal chest X-ray, blood painted