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据克山病病区流行病学调查提供的低硒事实及亚硒酸钠对克山病的防治效果,证明硒对克山病有防治作用。但亚硒酸钠对动物急性缺氧条件下耐受时间报道较少,本文主要是对正常小鼠给生理盐水和注射亚硒酸钠后小鼠的急性耐乏氧时间的实验研究,观察两组的差异,现将试验结果报道如下。1 材料和方法 药品Na_2SeO_3系天津化学试剂三厂出品,无水粉剂,分析纯。无水粉剂的Na_2SeO_3用蒸水配制而成。 Na_2SeO_3急性LD_(50)实验:小白鼠120只,体重18～20g,雌、雄各半,按对数剂量分成6组,每组20只,一次给亚硒酸钠(灌胃)观察72h内死亡数。
According to the epidemiological investigation of Keshan disease ward provided by low selenium facts and sodium selenite Keshan disease prevention and control of the effect of selenium on Keshan disease prevention and treatment. However, sodium selenite is less tolerant to acute hypoxia in animals. This paper mainly focuses on the experimental study of acute hypobaric hypoxia in normal mice and normal sodium selenite injection. The difference is now reported as follows test results. 1 Materials and Methods Drugs Na_2SeO_3 Department of Tianjin Chemical Reagent Factory produced, anhydrous powder, analytical grade. Na_2SeO_3 anhydrous powder formulated with distilled water. Na_2SeO_3 Acute LD_ (50) Experiment: 120 mice, body weight 18 ~ 20g, female and male half, according to the logarithmic dose divided into 6 groups, each group 20, once to sodium selenite (intragastric) observed within 72h The number of deaths.