论文部分内容阅读
在人工高温条件下,造成麻醉兔过热,观察侧脑室注射纳洛酮对动脉压力反射敏感性(ABS)的影响。动物分成两组:对照组与纳洛酮处理组。在对照组当直肠温度超过39℃以后,ABS呈阶梯性下降;至42℃时平均动脉压(MAP)显著下降。在过热过程中该组动物的存活率为58.3%。可是在纳洛酮组却很不相同,当直肠温度升至42℃时ABS仍无明显变化,至43℃时才明显下降,但此时MAP尚维持在90mnHg左右;该组动物的存活率为88.9%。结果表明,在高温中家兔过热时ABS呈进行性下降,而纳洛酮却可阻止或减弱ABS的下降,提示ABS的下降可能与β-内啡肽的释放增加有关。
Under artificial high temperature conditions, the anesthetized rabbits were overheated, and the effect of intracerebroventricular injection of naloxone on arterial pressure reflex sensitivity (ABS) was observed. Animals were divided into two groups: control group and naloxone-treated group. In the control group, when the rectal temperature exceeds 39 ℃, ABS showed a step decline; mean arterial pressure (MAP) decreased significantly to 42 ℃. The survival rate of this group of animals during overheating was 58.3%. But in the naloxone group is very different, when the rectal temperature rose to 42 ℃, ABS still no significant change to 43 ℃ decreased significantly, but at this time MAP remained at 90mnHg; survival rate of this group of animals 88.9%. The results showed that during the overheating of rabbits, the ABS decreased progressively while Naloxone prevented or attenuated the decrease of ABS, suggesting that the decrease of ABS may be related to the increase of β-endorphin release.