帕金森病患者的大脑的多巴胺分泌神经元将不可抗拒地相继死亡;最常用的控制患者肢体震颤、行动迟缓、肌肉僵直等症状的药物是多巴胺前体物质——左旋多巴,但该药应用一段时间后的疗效下降,患者将产生症状时轻时重的“开-关”周期;在病情加重阶段,患者常常十分衰弱。 Dopamine-secreting neurons in the brain of patients with Parkinson’s disease will die irresistibly one after another; the most commonly used drug for controlling symptoms such as tremor, bradykinesia, and muscle rigidity is the dopamine precursor, levodopa, After a period of reduced efficacy, the patient will have symptoms of light heavy “on-off” cycle; in the exacerbation phase, patients are often very weak.