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从化合物5出发,首先通过C-3位羟基的转位反应制得(+)-新黄皮酰胺(1)的前体化合物4,然后经过酮羰基的还原反应合成得到(+)-新黄皮酰胺(1).提供了一种简洁的(+)-新黄皮酰胺的全合成路线.考察了化合物5中C-3位羟基的转位反应的实验条件.
Starting from compound 5, the precursor compound 4 of (+)-neoxanthamide (1) is firstly prepared by the transposition reaction of the hydroxyl group at the C-3 position and then synthesized by the reduction reaction of the ketone carbonyl group to give (+)-new yellow. Skinamide (1). Provides a simple (+)-new yellow chalcamide full-synthetic route. The experimental conditions for the translocation of the C-3 hydroxyl group in compound 5 were investigated.