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目的:探讨EPO多克隆抗体是否具有对抗EPO促红系形成的功能。方法:对大鼠骨髓进行定向体外红系集落形成单位(CFU-E)培养,观察CFU-E数量,判定EPO多克隆抗体对红系增殖活性的影响。结果:与常规培养组比较,EPO多克隆抗体培养组CFU-E明显减少,P<0.01,差别有非常显著性。结论:EPO抗体可抑制EPO促红系形成,其可作为治疗高原红细胞增多症病人的药物进一步研究。
OBJECTIVE: To investigate whether EPO polyclonal antibodies have the function of antagonizing EPO erythroid formation. Methods: The bone marrow of rats were cultured in vitro by CFU-E. The number of CFU-E was observed to determine the effect of polyclonal antibody against erythrocytes on erythrocyte proliferative activity. Results: Compared with the conventional culture group, the CFU-E of EPO polyclonal antibody group was significantly decreased, P <0.01, the difference was very significant. Conclusion: EPO antibody can inhibit the erythropoiesis of EPO, which can be used as a drug for the treatment of patients with high altitude polycythemia.