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目的:研究鹿筋胶原对大鼠佐剂性关节炎的治疗作用。方法:以完全弗氏佐剂(CFA)诱导的Wistar雄性大鼠佐剂性关节炎(AA)为研究对象,观察经鹿筋胶原治疗前后的足趾肿胀度、体重、血清中的IL-lβ和TNF-α炎性细胞因子、血清中的MDA含量和SOD活力。结果:鹿筋胶原可显著抑制AA大鼠原、继发性足肿胀度,抑制AA大鼠炎性细胞因子IL-lβ和TNF-α分泌,增强SOD活性,降低MDA含量。结论:鹿筋胶原对弗氏佐剂诱导的大鼠佐剂性关节炎有明显的治疗作用。
Objective: To study the therapeutic effect of Lujin collagen on adjuvant arthritis in rats. METHODS: Adjuvant arthritis (AA) in Wistar male rats induced by complete Freund’s adjuvant (CFA) was studied. The degree of toe swelling, body weight, and IL-lβ in serum before and after treatment with Lujin collagen were observed. And TNF-alpha inflammatory cytokines, serum MDA content and SOD activity. RESULTS: Deer muscle collagen could significantly inhibit the degree of primary and secondary foot swelling in AA rats, inhibit the secretion of inflammatory cytokines IL-lbeta and TNF-alpha in AA rats, increase the activity of SOD, and decrease the content of MDA. CONCLUSION: Lujin collagen has obvious therapeutic effect on Freund’s adjuvant-induced adjuvant arthritis in rats.