论文部分内容阅读
目的:探讨布地奈德混悬液空气压缩驱动雾化吸入对早产儿机械通气后喉损伤的临床疗效。方法:本院新生儿科85例机械通气后喉损伤的早产儿,随机分治疗组44例和对照组41例,治疗组撤机拔管后予布地奈德混悬液空气压缩驱动雾化,对照组给予地塞米松超声雾化及琥珀氢化可的松静脉滴注,观察两组患儿喉梗阻症状消失时间、动脉血气指标及并发症情况。结果:治疗组吸气性凹陷时间和声嘶(喘鸣)消失时间为(2.00±0.95)d和(2.15±1.20)d,短于对照组的(2.51±1.32)d和(2.85±1.65)d,两组比较差异有统计学意义(P<0.05);治疗组气促消失时间为(2.56±1.74)d,短于对照组的(2.90±1.84)d,两组比较差异无统计学意义(P>0.05)。两组患儿拔管后及24 h动脉血气监测均大致正常,差异无统计学意义(P>0.05);雾化期间治疗组并发症的发生率低于对照组,差异无统计学意义(P>0.05)。结论:布地奈德混悬液空气压缩驱动雾化吸入能更好改善早产儿机械通气后喉梗阻临床症状,稳定患儿动脉血氧分压和二氧化碳分压,对早产儿机械通气后喉损伤有一定的治疗作用。
Objective: To investigate the clinical efficacy of inhalation of budesonide suspension by air compression in the treatment of premature infantile laryngeal injury after mechanical ventilation. Methods: A total of 85 neonates with premature laryngeal injury after mechanical ventilation were randomly divided into treatment group (n = 44) and control group (n = 41). The patients in the treatment group received air compression of budesonide suspension after extubation, Group was given dexamethasone ultrasonic atomization and amber hydrocortisone intravenous infusion, observed the disappearance of laryngeal obstruction symptoms, arterial blood gas index and complications in both groups. Results: The disappearance time of inspiratory depression and hoarseness were (2.00 ± 0.95) days and (2.15 ± 1.20 days) in treatment group, which were shorter than those in control group (2.51 ± 1.32 days and 2.85 ± 1.65 days, d, there was significant difference between the two groups (P <0.05). The disappearance time of shortness of breath in treatment group was (2.56 ± 1.74) d, shorter than that of control group (2.90 ± 1.84) d, there was no significant difference between the two groups (P> 0.05). The arterial blood gas monitoring in both groups was generally normal after extubation and at 24 hours, with no significant difference (P> 0.05). The incidence of complications in the treatment group was lower than that in the control group (P > 0.05). Conclusion: Air-entrapment of budesonide suspension can improve the clinical symptoms of laryngeal obstruction after mechanical ventilation and stabilize arterial partial pressure of oxygen and partial pressure of carbon dioxide in premature infants. Certain therapeutic effect.