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以第2代抗体法分析急、慢性肝病患者中丙型肝炎病毒(HCV)感染,并对HCV阳性者以型别特异的逆转录聚合酶链反应进行C基因分型,在644例肝病患者中,第2代抗体阳性率为肝癌7.3%、急性肝炎3.4%、慢性肝炎6.6%、肝硬化6.6%;非肝病患者106例中,阳性串为3.8%。慢性肝炎HBV感染达89.5%。41例HCV阳性者的C基因公型显示:Ⅱ型占85.4%、Ⅲ型7.3%、Ⅱ/Ⅲ混合型7.3%,未见其他型感染。本文资料提示,南通地区HCV感染以Ⅱ型为主,其感染卒远较HBV感染为低。
The second generation antibody method was used to analyze hepatitis C virus (HCV) infection in patients with acute and chronic liver diseases. Genotype C was genotyped by type-specific reverse transcription polymerase chain reaction in HCV-positive patients. In 644 patients with liver disease The positive rate of the second generation antibody was 7.3% for hepatocellular carcinoma, 3.4% for acute hepatitis, 6.6% for chronic hepatitis and 6.6% for cirrhosis; in the non-liver disease patients, the positive rate was 3.8%. Chronic hepatitis HBV infection reached 89.5%. The 41 cases of HCV-positive C gene male model shows: Ⅱ accounted for 85.4%, Ⅲ 7.3%, Ⅱ / Ⅲ mixed 7.3%, no other type of infection. The information in this paper suggests that HCV infection in Nantong area is mainly type Ⅱ, and its infection rate is far lower than that of HBV infection.