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目的:探讨盐酸文拉法辛联合自拟中药方治疗抑郁症的疗效及对患者血清单胺类神经递质的影响。方法:收治的抑郁症患者200例,按照随机数字表法分为治疗组100例和对照组100例。对照组口服盐酸文拉法辛,治疗组在对照组基础上服用自拟中药方。两组疗程均为8周。结果:治疗组总有效率(92.00%)高于对照组(79.00%),且有统计学差异(P<0.05);治疗组患者治疗后HAMD评分低于对照组,ADL评分高于对照组,且有统计学差异(P<0.05);治疗组患者治疗后血清DA、NE、5-HT水平高于对照组,且有统计学差异(P<0.05);治疗组患者治疗后心烦易怒、精神抑郁、情绪不宁积分低于对照组,且有统计学差异(P<0.05);治疗组不良反应发生率(10.00%)低于对照组(36.00%),且有统计学差异(P<0.05)。结论:盐酸文拉法辛联合自拟中药方治疗抑郁症的疗效显著,调节患者血清单胺类神经递质的代谢水平,具有重要意义。
Objective: To investigate the curative effect of venlafaxine combined with self-made traditional Chinese medicine prescription on depression and its influence on serum monoamine neurotransmitter. Methods: Depression patients admitted in 200 cases, according to the random number table divided into treatment group 100 cases and control group 100 cases. The control group oral venlafaxine hydrochloride, the treatment group on the basis of the control group taking self-prescription. The two groups were treated for 8 weeks. Results: The total effective rate (92.00%) in the treatment group was significantly higher than that in the control group (79.00%) (P <0.05). The HAMD score of the treatment group was lower than that of the control group, and the ADL score was higher than that of the control group (P <0.05). After treatment, the levels of serum DA, NE and 5-HT in the treatment group were significantly higher than those in the control group (P <0.05). After treatment, the patients in the treatment group were upset and irritable, (P <0.05). The incidence of adverse reactions in the treatment group (10.00%) was lower than that in the control group (36.00%), and there was a significant difference (P < 0.05). Conclusion: Venlafaxine hydrochloride combined with self-made traditional Chinese medicine prescription has significant curative effect on depression. It is important to regulate the level of monoamine neurotransmitter in patients.