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目的旨在为临床在应用rtPA溶栓方面找到一个更好更安全的方案。方法通过比较小剂量50mgrtPA30min与60min快速给药治疗急性ST段抬高性心肌梗死患者的效果89例,随机分为两组:rtPA30min给药和60min给药,比较两组患者临床疗效、冠脉再通率、心脏事件发生率、并发症以及急性期病死率。结果30min给药组再通率高达84.7%,与60min给药组比较患者临床症状改善和冠状动脉再通率均差异有显著性,梗死后心绞痛、再灌流心律失常发生率明显降低,出血并发症没有增加(P<0.05)。结论小剂量rtPA30min治疗AMI是安全可靠有应用价值值得推广的方法。
The purpose is to find a better and safer solution for the clinical application of rtPA thrombolysis. Methods Eighty-nine patients with acute ST-segment elevation myocardial infarction (AMI) treated with 50mgrtPA30min and 60min bolus were compared and randomly divided into two groups: rtPA30min and 60min. The clinical effects, Through rate, incidence of cardiac events, complications and mortality in acute phase. Results The recanalization rate was as high as 84.7% in the 30 min group. Compared with the 60 min group, the clinical symptoms and the rate of recanalization of coronary artery were significantly different. The incidence of post-infarction angina pectoris and reperfusion arrhythmia was significantly lower, and bleeding complications No increase (P <0.05). Conclusion The low dose rtPA30min treatment of AMI is safe and reliable, which is worthy of promotion.