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作者为３５例四肢恶性肿瘤切除后的骨缺损患者进行了大段同种异体骨移植重建，其中男性２３例，女性１２例。股骨下端和胫骨上端占６８．５％。骨肉瘤占４０％。所有病例均经术前、术后化疗。植骨材料来源于该院综合骨库。作者强调充分的术前准备，仔细选择匹配移植骨段，手术中注意设计骨膜袖套和软组织袖套以利于骨愈合。本组病例随访５个月～１０年，平均３年，其中无病存活者２５例，死亡６例，带病存活４例。部分患者于术后２年、４年进行移植骨段活检及９９ｍＴｅＳＰＥＣＴ骨扫描，显示骨段大部完成爬行替代。本组１０例出现１８个合并症，占２８．６％。骨接触端的紧密结合，坚强可靠的内固定或带锁髓内钉固定是有效减少骨不愈合的方法。作者认为，复合同种大段骨移植将成为今后发展的方向。
The authors performed large-scale allograft reconstruction in 35 patients with bone defects after excisional removal of limbs, including 23 males and 12 females. The lower femur and the upper tibia accounted for 68.5%. Osteosarcoma accounts for 40%. All cases were treated with preoperative and postoperative chemotherapy. The bone graft material comes from the hospital’s comprehensive bone bank. The authors emphasized adequate preoperative preparation and carefully selected matching bone grafts. During surgery, attention was paid to the design of periosteum sleeves and soft tissue sleeves to facilitate bone healing. This group of patients was followed up for 5 months to 10 years, with an average of 3 years, including 25 cases of disease-free survivors, 6 cases of death, and 4 cases of disease-free survival. Some patients underwent bone biopsy and 99mTeSPECT bone scans at 2 and 4 years postoperatively, showing that most of the bone segments were replaced by crawlers. Eighteen complications occurred in 10 patients in this group, accounting for 28.6%. The tight binding of the bone contact end, strong and reliable internal fixation or interlocking intramedullary nail fixation are effective methods to reduce nonunion. The authors believe that the same kind of large bone graft will become the direction of future development.