硝苯吡啶对支气管哮喘和慢性支气管炎的疗效观察大众机械厂职工医院（０３０００９）李金梅，米文瑞太原市药品检验所刘双树硝苯吡啶为较强的钙通道阻滞剂，我们自１９８７年以来，对患支气管哮喘和慢性支气管炎病人３３例给予硝苯吡啶治疗，现将结果如下。资料与方法３３例为我院及协作医院住院及门诊病例，其中２０例在发病前后做过血气测定，５例做过肺功能测定（已除外其他疾病）。①支气管哮喘１４例。其中１０例做血气测定，２例做肺功能测定，平均年龄３６岁。②慢性喘息型支气管炎１９例，３例做肺功能测定，１０例做血气测定。平均年龄５９岁。３３例在发病时，均有不同程度的肺部体征，以哮鸣为主。常规抗生素治疗后，喘息未减轻。方法：不用激素及其他平喘药，发作时患者舌下含化硝苯吡啶１０～２０ｍｇ，１５分钟后进行肺部体征检查，血气测定及肺功能测定。此后按１０ｍｇ一日三次，口服最大量每日达５０～６０ｍｇ。服药十日、用药期间，进行有关检查。结果服药１５分钟后，哮喘组多数有不同程度的自觉症状缓解，咳喘减轻，肺部哮鸣音减少。连续服药期间，症状缓解明显。显效、有效、效差分别为：２８．６％、５７．１％、１４．３％。慢支组少数有所缓解，肺部体征较度改善，连续服药期 Nifedipine on bronchial asthma and chronic bronchitis curative effect observation Public Machinery Factory Workers Hospital (030009) Li Jinmei, Mi Wenrui Taiyuan Institute of Drug Control Liu Shu Shu Shu Shunshu Nifedipine is a strong calcium channel blocker, since 1987 , For patients with bronchial asthma and chronic bronchitis were given nifedipine 33 cases, the results are as follows. Materials and Methods Thirty-three cases were hospitalized and outpatient cases in our hospital and collaborative hospital, of which 20 cases had blood gases measured before and after the onset of disease and 5 cases had lung function tests (excluding other diseases). ① bronchial asthma in 14 cases. Blood gas was measured in 10 cases and lung function in 2 cases with a mean age of 36 years. ② chronic wheezing bronchitis in 19 cases, 3 cases of lung function test, 10 cases of blood gas determination. The average age is 59 years old. 33 cases at onset, have different degrees of lung signs, mainly to wheezing. After conventional antibiotic treatment, wheezing did not reduce. Methods: Without hormones and other antiasthmatic drugs, patients under sublingual nifedipine 10 ~ 20mg, 15 minutes after the lung examination, blood gas determination and pulmonary function tests. Subsequent to 10mg three times a day, the maximum amount of oral daily up to 50 ~ 60mg. Medication on the 10th, medication, for the inspection. Results 15 minutes after taking the medication, most of the asthma group had different degrees of subjective symptoms relieved, relieved cough and wheeze decreased. During continuous medication, the symptoms were relieved. Effective, effective, effective difference was: 28.6%, 57.1%, 14.3%. A small number of chronic bronchitis relief, pulmonary signs of improvement, continuous medication period