自身免疫性疾病的发病存在明显的性别差异 ,女性的发病率常高于男性。文章就雌激素在自身免疫性疾病发生机制中的作用 ,特别是近年来雌激素对免疫细胞信号传导、细胞分化、下丘脑 -垂体 -肾上腺 ( HPA )轴的激活、自身免疫性疾病的发生和缓解等方面的研究作一介绍 ,进一步探讨雌激素调节异常对自身免疫性疾病发生的影响。 The incidence of autoimmune diseases, there are significant gender differences, the incidence of women is often higher than men. The article discusses the role of estrogen in the pathogenesis of autoimmune diseases, especially in recent years estrogen on immune cell signaling, cell differentiation, hypothalamic-pituitary-adrenal (HPA) axis activation, autoimmune diseases and Mitigation and other aspects of an introduction to further explore the impact of abnormal estrogen regulation on the occurrence of autoimmune diseases.