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目的：观察国产低分子肝素钠与进口低分子肝素钠治疗不稳定性心绞痛的有效性和安全性。方法80例不稳定性心绞痛患者按1：1随机分为国产低分子肝素钠组（治疗组）和进口低分子肝素钠组（对照组）。观察住院期间疗效及安全性指标，记录住院期间及随访3个月的主要不良心脏事件(major adverse cardiac events，MACE)。结果进口低分子肝素钠组40例，总有效率为90%,价格依从性良好率75%。国产低分子肝素钠组40例，总有效率为87.5%，价格依从性良好率达100%。两组疗效对比差异无明显统计学意义（P>0.05），而治疗组有较好的价格依从性(P0.05）。结论与进口低分子肝素钠相比，国产低分子肝素钠治疗不稳定性心绞痛同样安全有效，且有较好的价格依从性。“,”Objective To compare the efficacy and safety of imported and domestic low-molecular weight heparin( LMWH) sodium on ustable angino(UA).Methods 80 patients with UA were divided into two groups randomly, domestic LMWH sodium group(treatment group) , imported LMWH sodium group( control group). Efficacy and safety was observation in the hospital. The events of AMI, angina pectoris rehospitalization,PCI and death in three months and AMI, ventricular fibril ation /ventricular tachycardia , transfer PCI and death during hospitalization were observed. At the same time, The events of hemorrhage and thrombocytopenia were recorded. Results Control group 40 cases, the total effective rate was 90%, the price compliance rate was 75%.Treatment group 40 cases, 87.5% and 100% correspondingly.Curative effect difference has no significance betwen two groups (P > 0.05), while the treatment group has better price compliance (P 0.05) betwen two groups of about MACE in 3 months and bleeding,thrombocytopenia event during hospitalization(P > 0.05).Conclusion The domestic LMWH sodium is as safe and effective as imported LMWH sodium in the treatment of UA. And The domestic LMWH sodium has better prices compliance.