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目的研究糖皮质激素治疗小儿社区获得性支原体肺炎的疗效及安全性分析。方法选取2013年9月至2014年10月就诊于深圳市儿童医院的社区获得性支原体肺炎患儿82例,按照随机数字表法分为对照组(n=41)和观察组(n=41),均给予祛痰、退热、氧疗、雾化、补液、镇静等对症治疗,对照组给予阿奇霉素治疗,用药3 d,间隔4 d后再继续用药3 d,观察组在上述治疗基础上加用小剂量泼尼松口服,上述治疗手段持续给药1周,观察两组患儿临床疗效及不良反应发生情况。结果观察组住院时间(5.51±1.53)d、退热时间(3.12±1.14)d、咳嗽消失时间(8.96±2.37)d、X线阴影吸收时间(7.58±2.49)d,均显著短于对照组[(8.76±3.01)d、(5.61±1.54)d、(12.84±3.41)d、(12.04±3.52)d],差异均有统计学意义(P<0.05);观察组不良反应发生率(9.76%)与对照组(19.5%)比较差异未见统计学意义(P>0.05)。结论糖皮质激素治疗小儿社区获得性支原体肺炎可加快康复进程,安全性高,值得推广。
Objective To study the efficacy and safety of glucocorticoid in the treatment of pediatric community acquired mycoplasma pneumonia. Methods Eighty-two children with community acquired mycoplasma pneumonia admitted to Shenzhen Children’s Hospital from September 2013 to October 2014 were randomly divided into control group (n = 41) and observation group (n = 41) , Were given expectorant, antipyretic, oxygen therapy, atomization, rehydration, sedation and other symptomatic treatment, the control group was treated with azithromycin, medication 3 d, 4 d after the continued medication for 3 d, the observation group on the basis of the above treatment With a small dose of prednisone oral administration of the above treatment continued for 1 week to observe the clinical efficacy and adverse reactions in both groups. Results The length of hospital stay (5.51 ± 1.53) d, antipyretic time (3.12 ± 1.14) days, cough disappearing time (8.96 ± 2.37) days and X-ray shading time (7.58 ± 2.49) days in observation group were significantly shorter than those in control group The difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group (9.76 ± 3.01 days, 5.61 ± 1.54 days, 12.84 ± 3.41 days, 12.04 ± 3.52 days, respectively) %) Compared with the control group (19.5%) showed no significant difference (P> 0.05). Conclusion Glucocorticoid treatment of children with community acquired mycoplasma pneumonia can speed up the recovery process, high safety, it is worth promoting.