论文部分内容阅读
目的 :探讨CyclinE和 p5 3的同时表达对预测粘膜下层胃癌预后的作用。 方法 :用免疫组化法检测 48例粘膜下层胃癌中CyclinE和p5 3的表达。 结果 :粘膜下层胃癌中CyclinE阴性、阳性和强阳性组的p5 3表达率分别为 19% (5 / 2 7)、42 % (5 / 12 )、89% (8/ 9) (P <0 .0 1)。同时表达的总发生率为 2 7% (13/ 48)。同时表达的发生率分别为 :幽门部癌 46 % (11/ 2 4) ,侵入淋巴结者 6 0 % (6 / 10 ) ,均显著高于对照组。分化型 33 % (13/ 39) ,高于未分化型者。同时表达癌的 5年生存率仅 46 % (6 / 13) ,显著低于各非同时表达组。结论 :CyclinE和p5 3同时表达的粘膜下层胃癌恶性度高 ,预后差 ;同时表达有助于预测粘膜下层胃癌的预后。
Objective: To investigate the role of simultaneous expression of CyclinE and p5 3 in predicting prognosis of submucosal gastric cancer. Methods: The expressions of CyclinE and p5 3 in 48 cases of submucosal gastric cancer were detected by immunohistochemistry. Results: The positive rates of p5 3 in positive group and negative group were 19% (5/27), 42% (5/12) and 89% (8/9) respectively (P <0. 0 1). The overall incidence of simultaneous expression was 27% (13/48). The incidence rates of pyloric carcinoma were 46% (11/2 4) in pyloric carcinoma and 60% (6/10) invaded lymph nodes, which were significantly higher than those in control group. Differentiation type 33% (13/39), higher than undifferentiated type. At the same time, the 5-year survival rate of cancer was only 46% (6/13), significantly lower than that of non-concurrent expression group. Conclusions: The submucosal gastric carcinoma with simultaneous expression of CyclinE and p5 3 has high malignancy and poor prognosis. Simultaneous expression of p21 and CyclinE may be helpful in predicting the prognosis of gastric cancer with submucosa.