轮状病毒在世界各地是婴幼儿胃肠炎的一个重要病因。虽然其流行病学及病毒学方面已作了较多的研究,但对其致病性的影响因素仍缺乏了解。本文报道了18位“志愿者”口服人类轮状病毒 D 株(亚群2,血清型 Wa)后的发病情况及影响因素。研究对象为健康的男性和女性,年龄18～35岁。接种用的轮状病毒为一住院腹泻儿童的粪便。已经血清学鉴定证实富含轮状 Rotavirus is an important cause of gastroenteritis in infants and young children around the world. Although more studies have been done on its epidemiology and virology, its influence on pathogenicity is still poorly understood. This article reports the incidence and influencing factors of 18 human volunteers oral human rotavirus D strains (subgroup 2, serotype Wa). Study for healthy men and women, aged 18 to 35 years. Inoculated rotavirus is a droppings of children in hospital diarrhea. Has been serologically confirmed rich round