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作者同意Rombo及其同事关于氯胍在多重抗性恶性疟流行区预防用药应予重新考虑的意见。但认为他们的结果可能给人一种乐观的错觉。在半免疫儿童中,无症状的原虫血症未经任何特别治疗也常常自然消失。若设一个不治疗的对照组就可证实这一观点。Rombo等曾给50例具有原虫血症的儿童每天服用氯胍100mg,于一周疗程结束时作血片检查,其中39例阴性。他们未详细说明所作血片是否是厚血膜片。但作者感到如作厚血膜片检查,就难以相信没有在每200
The authors agree with Rombo and colleagues on the re-consideration of the potential of proguanil in the prophylaxis of multi-resistant falciparum malaria-endemic areas. But their results may give the optimistic illusion. In semi-immunized children, asymptomatic parasitemia often disappears spontaneously without any special treatment. If an untreated control group can confirm this view. Rombo et al. Gave 50 daily doses of proguanil to 100 children with parasitemia for a blood test at the end of the week, 39 of which were negative. They did not specify whether the blood film made was a thick film. However, the author feels like a thick film check, it is hard to believe that there is not every 200