搜集已报道的在乳腺癌发生发展过程中有重要作用的micro RNA信息,结合相关肿瘤模型的实验数据,评估micro RNA在乳腺癌诊断和治疗方面的应用前景。以“癌基因”和“癌抑制基因”为分类依据,全面地总结归纳乳腺癌相关micro RNA的功能和作用机制,进一步从临床诊断标记物和治疗靶点的层面分析micro RNA的潜在临床应用价值。表1和2总结了micro RNA参与乳腺癌发展过程的具体事件及其调控的靶基因。同时,本文还深入探讨micro RNA作为临床诊断标记物及治疗靶点的可行性,揭示已有研究的不足之处,为今后的相关工作方向提供一些建议。 We have collected the reported micro RNA information that plays an important role in the development of breast cancer and combined with the experimental data of the relevant tumor models to evaluate the application of microRNA in the diagnosis and treatment of breast cancer. Based on the classification of “oncogene ” and “cancer suppressor gene ”, we comprehensively summarize the function and mechanism of breast cancer-related microRNAs, and further analyze the microRNA from the level of clinical diagnostic markers and therapeutic targets Potential clinical value. Tables 1 and 2 summarize the specific events involved in the development of breast cancer and the target genes that microRNAs regulate. At the same time, this article also in-depth discussion of the feasibility of microRNA as a clinical diagnostic marker and therapeutic target, reveal the deficiencies of the existing research, and provide some suggestions for the future work direction.