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继中国蘿芙木之后,最近在云南又发現狹叶蘿芙木(Rauwolfia yunnanensis Tsiang var.angustifolia C.Y.Wu.)。其根生物碱对麻醉动物具降压作用,給犬靜脉注射1毫克/公斤后2小时內的降压面积为-32％,給猫靜脉注射3毫克/公斤的降压面积为-30％。同时測得中国蘿芙木根生物碱在犬的降压面积为-45％,猫为-29％。重复給药有快速耐受性。降压的同时呼吸呈兴奋,对心率影响不明显。降压作用与M-胆碱能反应系統、N-胆碱能反应系統以及內感受器都无关系。对血管也无直接作用,单側頸交感神經切除兔耳試驗发現,扩张血管的作用与交感神經有关。狹叶蘿芙木根生物碱可抑制腎上腺素或去甲腎上腺素的加压反应,也可抑制阻断頸总动脉血流和电刺激迷走神經或胫骨神經中枢端所致的加压反射。用脊猫試驗吋其降压作用大为減弱,但并不完全消除,降压面积仅为-14％。因此,其降压机制包括中枢和外周两方面,即对血管运动中枢的抑制作用和抗腎上腺素的作用。急性毒性試驗証明,狹叶蘿芙木根生物碱的毒性很小,小鼠口服2000毫克/公斤无死亡发生,动物呈現安靜状态。
Following Rauvolfia in China, Rauwolfia yunnanensis Tsiang var. Angustifolia C.Y.Wu. was also recently found in Yunnan. Its root alkaloids exerted antihypertensive action on anesthetized animals, giving an antihypertensive area of -32% within 2 hours after intravenous injection of 1 mg / kg of dog and -30% of intravenous injection of 3 mg / kg into cats. Measured at the same time China Rauvolfia alkaloids in dogs in the antihypertensive area -45%, cats -29%. Repeated administration has rapid tolerance. Antihypertensive breath was excited at the same time, the impact on heart rate is not obvious. Antihypertensive effects are independent of the M-cholinergic system, the N-cholinergic system, and the endoreceptor. No direct effect on the blood vessels, unilateral cervical sympathectomy rabbit ear test found that the role of dilation of blood vessels and sympathetic. Scutellaria radix alkaloids inhibit the pressure response of epinephrine or norepinephrine, and also inhibit the reflex caused by blocking the common carotid artery blood flow and electrically stimulating the vagus nerve or the tibial nerve center. With ridges cat test inch its antihypertensive effect greatly weakened, but not completely eliminated, blood pressure area is only -14%. Therefore, its antihypertensive mechanism includes both central and peripheral aspects, that is, inhibition of the vasomotor center and anti-epinephrine effect. Acute toxicity test showed that the toxicity of small-leaf Rauwolfia alkaloids is very small, mice without oral death occurred 2000 mg / kg, the animals showed a quiet state.