多糖是一种重要的生物高分子物质,降血糖是其重要生物功能之一。研究表明,多糖基团对其降血糖活性起重要作用,故可通过修饰多糖分子结构来影响其降血糖活性。该文阐述多糖的硫酸化、脱硫酸化、乙酰化等分子修饰方法及修饰后的多糖对降血糖活性的影响,并展望多糖分子修饰的应用前景。 Polysaccharide is an important biological macromolecules, hypoglycemic is one of its important biological functions. Studies have shown that polysaccharide groups play an important role in its hypoglycemic activity, it can be modified polysaccharide molecular structure to influence its hypoglycemic activity. This article describes the polysaccharide sulfation, desulfation, acetylation and other molecular modification methods and modified polysaccharides on hypoglycemic activity, and prospects of polysaccharide molecular modification of the application prospects.