论文部分内容阅读
目的研究微泵控制换血治疗新生儿重症高胆红素血症的疗效与安全性。方法选取30例重症高胆红素血症的新生儿为研究对象,对其采用微泵控制换血治疗,对比治疗前后新生儿血清胆红素的变化。结果 30例重症高胆红素新生儿均顺利进行了换血治疗,一次成功,平均治疗时间为(158.22±2.47)min。治疗后总胆红素为(313.23±12.26)μmol/L,直接胆红素为(10.74±7.23)μmol/L,间接胆红素为(323.37±11.31)μmol/L,低于治疗前的(521.47±14.85)、(46.61±8.22)、(474.84±13.23)μmol/L,差异有统计学意义(P<0.05)。总胆红素排除率为40.00%,直接胆红素排除率为76.96%,间接胆红素排除率为30.00%。新生儿平均住院时间为(8.4±1.7)d,住院期间30例新生儿均未出现不良反应,均治疗痊愈后出院。结论采用微泵控制换血治疗新生儿重症高胆红素血症,能够显著降低新生儿血清胆红素,并且无不良反应发生,安全性高,具有临床推广价值。
Objective To study the therapeutic effect and safety of micro pump controlled transfusion in the treatment of neonatal severe hyperbilirubinemia. Methods Thirty newborns with severe hyperbilirubinemia were selected as the study object. The micro-pump controlled transfusion was used to compare the changes of serum bilirubin in neonates before and after treatment. Results All 30 severe hyperbilirubine neonates were successfully transfused. The first successful treatment was (158.22 ± 2.47) min. The total bilirubin (313.23 ± 12.26) μmol / L, the direct bilirubin (10.74 ± 7.23) μmol / L, and the indirect bilirubin (323.37 ± 11.31) μmol / L after treatment were lower than those before treatment 521.47 ± 14.85), (46.61 ± 8.22) and (474.84 ± 13.23) μmol / L, respectively. The difference was statistically significant (P <0.05). Total bilirubin exclusion rate was 40.00%, direct bilirubin exclusion rate was 76.96%, indirect bilirubin exclusion rate was 30.00%. The average length of stay in newborns was (8.4 ± 1.7) days. There were no adverse reactions in 30 newborns during hospitalization. All patients were discharged after treatment. Conclusion Micro-pump controlled transfusion of blood in neonates with severe hyperbilirubinemia can significantly reduce neonatal serum bilirubin, and no adverse reactions, high safety, and has clinical value.