随着不稳定膀胱中阿托品抵抗性逼尿肌收缩的深入研究,学者们发现膀胱逼尿肌收缩和膀胱充盈两方面功能除了接受M受体支配外,嘌呤受体(P2X受体)传导途径也参与逼尿肌感觉和运动功能的调节。病理条件下,P2X受体传导途径在泌尿系统病理生理中的作用越来越明显,P2X受体与膀胱过度活动症之间的关系越来越受到重视。本文就膀胱过度活动症时P2X各亚型在逼尿肌上的表达异常和功能异常与膀胱过度活动症之间可能存在的联系作一综述。 With an in-depth study of atropine-resistant detrusor contractions in unstable urinary bladder, scholars have found that detrusor contraction and filling of the bladder both function in addition to accepting the M receptors, the purinergic receptor (P2X receptor) Involvement of detrusor sensation and motor function. Pathological conditions, P2X receptor transduction pathway in the pathophysiology of the urinary system more and more obvious, P2X receptor and overactive bladder more and more attention to the relationship between. In this paper, the possible relationship between the abnormal expression of P2X isoforms and overactive bladder in detrusor ova during overactive bladder was reviewed.