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目的:研究三氧化二砷治疗白血病的新价值,并对机理进行探讨。方法:三氧化二砷注射液加至10%葡萄糖注射液500ml中,给予白血病患者静脉滴注,qd,30d为一疗程。结果:15例白血病患者中,急性早幼粒细胞白血病(APL)13例,9例完全缓解(CR),CR率69.2%,2例部分缓解(PR),PR率15.4%,有效率达84.6%;慢性粒细胞白血病(CML)2例,1例CR,1例PR。9例CR的APL,其中5例已达1年以上。结论:三氧化二砷治疗白血病的疗效肯定,且近期疗效高,远期疗效亦尚好
Objective: To study the new value of arsenic trioxide in the treatment of leukemia and discuss the mechanism. Methods: Arsenic trioxide injection was added to 500ml of 10% glucose injection and administered intravenously to patients with leukemia. qd, 30d was a course of treatment. Results: Of the 15 leukemia patients, 13 were acute promyelocytic leukemia (APL), 9 were complete remission (CR), CR rate was 69.2%, 2 were partial remission (PR), PR rate was 15.4%, and the effective rate was 84.6. %; 2 cases of chronic myeloid leukemia (CML), 1 CR, 1 PR. 9 cases of APL of CR, of which 5 cases have been more than 1 year. Conclusion: The efficacy of arsenic trioxide in the treatment of leukemia is positive, and the curative effect is high in the short term and the long-term efficacy is still good.