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目的探讨煤工尘肺患者血清白介素18抗体(antibody against Interleukin 18,anti-IL-18)与类风湿因子(rheumatoid factor,RF)的表达水平及两者的相关性。方法采用间接酶联免疫吸附法(enzyme-linked-immunosorbent serologic assay,ELISA)对328例煤工尘肺患者、230例观察对象、309例接尘者及393例健康对照者血清IL-18抗体及RF的表达水平进行检测。结果病例组、观察对象组及接尘组人群血清IL-18抗体及RF的表达水平均高于健康对照组,差异有统计学意义(均有P<0.05);贰期煤工尘肺患者血清IL-18抗体的表达水平高于壹期尘肺患者(P=0.019),叁期尘肺与壹期尘肺相比患者血清IL-18抗体表达水平差异无统计学意义(P=0.067)。不同X线分期患者血清RF的表达差异无统计学意义(P=0.765);Spearman相关分析结果显示,各组中IL-18抗体与RF间均不存在相关性。结论煤工尘肺患者血清IL-18抗体及RF均存在高表达,且在一定范围内随X射线胸片表现分期的增高表达升高;但是两者间不存在相关性,提示IL-18抗体及RF可能通过不同的作用机制参与煤工尘肺发生发展。
Objective To investigate the expression of serum anti-IL-18 and rheumatoid factor (RF) in patients with coal worker’s pneumoconiosis and their relationship. Methods The serum levels of IL-18 and IL-18 in 328 cases of coal workers with pneumoconiosis, 230 cases of observation, 309 cases of dust exposure and 393 healthy controls were detected by ELISA. The level of expression was detected. Results The levels of serum IL-18 antibody and RF in the case group, the observation group and the dust-exposed group were significantly higher than those in the healthy control group (all P <0.05). The serum IL (P = 0.019). There was no significant difference in serum IL-18 antibody level between the three stage pneumoconiosis and the one stage pneumoconiosis (P = 0.067). There was no significant difference in the expression of RF in patients with different X-ray stages (P = 0.765). Spearman correlation analysis showed no correlation between IL-18 antibody and RF in each group. Conclusion The serum IL-18 antibody and RF of coal workers’ pneumoconiosis patients are highly expressed and increased with the increase of staging of X-ray in a certain range. However, there is no correlation between IL-18 antibody and RF RF may participate in the development of coal worker’s pneumoconiosis through different mechanisms of action.