CD147分子是细胞外基质金属蛋白酶(MMP)的诱导剂,在多种肿瘤细胞和组织中高表达,通过诱导MMP的分泌促进肿瘤的侵袭和转移。MMP在动脉粥样硬化的发生、发展和斑块破裂等心血管并发症的发生中起重要作用。论述了粥样斑块中CD147的表达、CD147对MMP的调控,以及MMP活化对斑块的形成、破裂、引发心肌梗死等急性心血管事件的关联性。 CD147 molecule is an extracellular matrix metalloproteinase (MMP) inducer, is highly expressed in a variety of tumor cells and tissues, and promotes tumor invasion and metastasis by inducing MMP secretion. MMP plays an important role in the occurrence of cardiovascular complications such as atherosclerosis, development and plaque rupture. Discussed the expression of CD147 in atherosclerotic plaques, the regulation of MMPs by CD147, and the relevance of MMP activation in the formation of plaque, rupture, and other acute cardiovascular events such as myocardial infarction.